Travel Medicine and Infectious Disease
Volume 7, Issue 6 , Pages 329-336, November 2009

Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: Retrospective observational data☆

  • Jane N. Zuckerman

      Affiliations

    • WHO Collaborating Centre for Reference, Research and Training in Travel Medicine, University College London Medical School, London, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 (0) 20 7830 2999; fax: +44 (0) 20 7830 2268.
    • ,
  • Anthony J. Batty

      Affiliations

    • GlaxoSmithKline, London, UK
    • ,
  • Michael E. Jones

      Affiliations

    • Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK

Received 14 September 2009; accepted 11 October 2009. published online 05 November 2009.

Summary 

What is already known on this topic

•Malaria is a potentially life-threatening disease, and cases of imported Plasmodium falciparum malaria have increased among UK travellers over the past 20 years, although declining steadily in recent years.

•The HPA Advisory Committee on Malaria Prevention (ACMP) UK Traveller guidelines recommend doxycycline, mefloquine, or combination atovaquone plus proguanil for prophylaxis in travellers to P. falciparum endemic regions, and with the exception of Lambeth Primary Care Trust, malaria chemoprophylaxis is not reimbursed by the NHS.

•There are limited data on the comparative effectiveness of the recommended malaria chemoprophylaxis drugs for P. falciparum.

What this study adds

•The effectiveness of combination atovaquone plus proguanil may provide greater protection against imported P. falciparum malaria in UK travellers as compared with doxycycline and mefloquine.

•More research is needed on the effectiveness of different chemoprophylactic regimens.

•Further work is required to ascertain whether ease of use and compliance may be important factors in the outcomes associated with malaria chemoprophylaxis.

Keywords: Malaria, Plasmodium falciparum, Chemoprophylaxis

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 12.00 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

☆ Preliminary results presented: Zuckerman JN, Batty AJ, Millard D, Jones ME. Observational Data on the Clinical Effectiveness of Malaria Chemoprophylaxis against Plasmodium falciparum Infection in UK Travellers: Preliminary Results. 11th Conference of the International Society of Travel Medicine; May 24–28, 2009.

PII: S1477-8939(09)00153-7

doi:10.1016/j.tmaid.2009.10.002

Travel Medicine and Infectious Disease
Volume 7, Issue 6 , Pages 329-336, November 2009

Article Tools

* Image Usage & Resolution